Open AccessTherapeutic drug monitoring of vancomycin in an obese patient with renal insufficiency
Author(s) -
Said Abuhasna,
Amer H Al Jundi
Publication year - 2011
Publication title -
journal of anaesthesiology-clinical pharmacology/journal of anaesthesiology clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.466
H-Index - 32
eISSN - 2231-2730
pISSN - 0970-9185
DOI - 10.4103/0970-9185.86601
Subject(s) - medicine , vancomycin , pharmacokinetics , dosing , therapeutic drug monitoring , trough level , trough concentration , urology , intensive care medicine , staphylococcus aureus , transplantation , tacrolimus , biology , bacteria , genetics
We report the pharmacokinetics of vancomycin in an obese patient with renal insufficiency using pharmacokinetic equations, and comparing them with actual levels. A 47-year-old man with morbid obesity had a complicated hospital course with acute renal failure. Due to sputum growth of coagulase-negative Staphylococcus aureus, vancomycin 1500 mg intravenously twice daily was given empirically. Peak and trough plasma concentrations were drawn at steady state. Based on levels, true pharmacokinetic parameters for the patient were calculated using equations. This revealed that calculating individual pharmacokinetic parameters using equations may be a valid tool for dosing vancomycin in obese patients with renal insufficiency.