Open AccessPre-emptive oral dexmethorphan reduces fentanyl-induced cough as well as immediate postoperative adrenocortico-tropic hormone and growth hormone level
Author(s) -
A. K. Mukherjee,
Anup Kumar Kundu,
Sudipta Ghosh,
Rajat Choudhuri,
Bijoy Kumar Bandopadhyay,
Sugata Dasgupta
Publication year - 2011
Publication title -
journal of anaesthesiology-clinical pharmacology/journal of anaesthesiology clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.466
H-Index - 32
eISSN - 2231-2730
pISSN - 0970-9185
DOI - 10.4103/0970-9185.86593
Subject(s) - dextromethorphan , medicine , anesthesia , fentanyl , placebo , adverse effect , incidence (geometry) , cough reflex , reflex , physics , alternative medicine , pathology , optics
Fentanyl-induced cough is not always benign and brief and can be remarkably troublesome, spasmodic, and explosive. Dextromethorphan, an opioid derivative with an antitussive action, may be effective in reducing the fentanyl-induced cough. Dextromethorphan, a N-methyl D aspartate receptor antagonist, may have some effect on diminishing the stress response to surgery. This study was undertaken to determine whether preoperative dextromethorphan could effectively attenuate its incidence, severity, and effect on postoperative stress hormone levels.