Open AccessAnti-interleukin-6 therapies for Covid-19: A systematic review, critical appraisal and meta-analysis
Author(s) -
Arunmozhimaran Elavarasi,
Ranjit Kumar Sahoo,
Tulika Seth,
S. Shalimar,
Karan Madan,
Neeraj Nischal,
Manish Soneja,
Atul Sharma,
Pramod Garg,
Kameshwar Prasad
Publication year - 2020
Publication title -
national medical journal of india
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.2
H-Index - 41
ISSN - 0970-258X
DOI - 10.4103/0970-258x.288119
Subject(s) - critical appraisal , covid-19 , meta analysis , medicine , systematic review , medline , intensive care medicine , virology , alternative medicine , political science , pathology , disease , outbreak , infectious disease (medical specialty) , law
. Coronavirus disease 2019 (Covid-19) has emerged as a pandemic by end-January 2020. Of the infected patients, 10%-15% may develop severe or critical illness. So far, no definite treatment is available for Covid-19. Cytokine release syndrome may underlie the pathogenesis of severe and critical disease. Anti-interleukin (IL)-6 therapies are being tried to improve clinical outcomes.