Open AccessRole played by Th2 type cytokines in IgE mediated allergy and asthma
Author(s) -
Sudha S Deo,
Kejal J Mistry,
Amol M. Kakade,
Pramod V. Niphadkar
Publication year - 2010
Publication title -
lung india
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.457
H-Index - 25
eISSN - 0974-598X
pISSN - 0970-2113
DOI - 10.4103/0970-2113.63609
Subject(s) - immunology , immunoglobulin e , medicine , allergy , eosinophil , immune system , asthma , cytokine , interleukin 4 , allergic response , antibody
Recent evidence suggest that allergen type 2 helper T cells (Th2) play a triggering role in the activation/recruitment of IgE antibody producing B cells, mast cells and eosinophils. Reduced microbial exposure in early life is responsible for a shift of Th1/Th2 balance in the immune system towards the pre-allergic Th2 response. The Th1 predominantly produce IFNgamma and delayed type hypersensitivity while Th2 secrete IL-4, IL-5, IL-6, IL-13 and regulate B cell and eosinophil mediated responses. To assess regulatory changes in the immune system, in patients with allergy and asthma, we studied the cytokine profile in serum in comparison with normal healthy controls.