Open AccessA positive magnetic resonance spectroscopic imaging with negative initial biopsy may predict future detection of prostate cancer
Author(s) -
Durgesh K. Dwivedi,
Virendra Kumar,
Tarun Javali,
Amit Kumar Dinda,
Sanjay Thulkar,
Naranamangalam R. Jagannathan,
Rajeev Kumar
Publication year - 2012
Publication title -
indian journal of urology/indian journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.333
H-Index - 30
eISSN - 1998-3824
pISSN - 0970-1591
DOI - 10.4103/0970-1591.98487
Subject(s) - medicine , prostate cancer , malignancy , biopsy , magnetic resonance imaging , magnetic resonance spectroscopic imaging , radiology , cancer , prostate , pathology
Current diagnostic modalities for early prostate cancer (PCa) lack sufficient sensitivity and specificity. Magnetic resonance spectroscopic imaging (MRSI) detects biochemical changes in tissues that may predate histological changes that can be diagnosed on a biopsy. Men with MRSI suggestive of malignancy but negative biopsy may thus be harboring cancer that manifests at a later date. We report the first case in our cohort of men with positive MRSI but negative initial biopsy who, 6 years after the initial MRSI, were detected to have PCa despite a "normal" prostate specific antigen (<4.0 ng/ml).