Open AccessDNA fragmentation and apoptosis induced by safranal in human prostate cancer cell line
Author(s) -
Saeed Samarghandian,
Mahmood Shabestari
Publication year - 2013
Publication title -
indian journal of urology/indian journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.333
H-Index - 30
eISSN - 1998-3824
pISSN - 0970-1591
DOI - 10.4103/0970-1591.117278
Subject(s) - safranal , propidium iodide , apoptosis , crocus sativus , mtt assay , microbiology and biotechnology , dna fragmentation , cytotoxicity , cell culture , medicine , flow cytometry , annexin , viability assay , cytotoxic t cell , cancer research , biology , programmed cell death , biochemistry , traditional medicine , in vitro , genetics
Apoptosis, an important mechanism that contributes to cell growth reduction, is reported to be induced by Crocus sativus (Saffron) in different cancer types. However, limited effort has been made to correlate these effects to the active ingredients of saffron. The present study was designed to elucidate cytotoxic and apoptosis induction by safranal, the major coloring compound in saffron, in a human prostate cancer cell line (PC-3).