Open AccessEfficacy of topical photodynamic therapy for keratoacanthomas: A case-series of four patients
Author(s) -
Marcelo Farías,
Ariel Hasson,
Cristián Navarrete,
Claudia Nicklas,
Isidora García-Huidobro,
Sergio González
Publication year - 2012
Publication title -
indian journal of dermatology, venereology, and leprology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.514
H-Index - 45
eISSN - 0973-3922
pISSN - 0378-6323
DOI - 10.4103/0378-6323.93634
Subject(s) - photodynamic therapy , medicine , actinic keratosis , dermatology , keratoacanthoma , basal cell carcinoma , basal cell , actinic keratoses , bowen's disease , keratosis , skin cancer , pathology , cancer , chemistry , organic chemistry
Topical photodynamic therapy (PDT) is an excellent treatment option for various non-melanoma skin cancers and precancerous lesions, including actinic keratosis, Bowen's disease, and basal cell carcinoma. The clinical use of PDT includes a broad range of neoplastic, inflammatory, and infectious skin diseases. There is also anecdotal evidence suggesting the efficacy of PDT for the treatment of keratoacanthomas (KA). We report a case-series of four patients with solitary KA confirmed by histology, treated with topical PDT with methylaminolevulinic acid (MAL) cream. After three sessions of PDT, the lesions completely disappeared. There was no evidence of recurrence and excellent cosmetic outcome was achieved after three years of follow-up. Topical photodynamic therapy with MAL can be a therapeutic alternative for KA with good clinical and cosmetic outcomes.