Open AccessThe effect of H1and H2receptor antagonists on melanogenesis
Author(s) -
Tag S. Anbar,
W. Westerhof,
Nafisa A Badawy,
Amal T. AbdelRahman,
Talal A Abd El-Raheem,
Saadea R Sayed,
Azza Hussein Ali,
H.T. Salem
Publication year - 2012
Publication title -
indian journal of dermatology, venereology, and leprology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.514
H-Index - 45
eISSN - 0973-3922
pISSN - 0378-6323
DOI - 10.4103/0378-6323.90948
Subject(s) - melanosome , antagonist , histamine , chemistry , pharmacology , receptor , melanin , receptor antagonist , histamine h1 receptor , endocrinology , biology , biochemistry
Histamine was found to stimulate melanogenesis in cultured human melanocytes specifically mediated by histamine H 2 receptors via protein kinase A activation. Based on this finding, the effect of topically applied H 2 antagonist on UVB-irradiated Guinea pigs' skin was examined and found to be suppressive on the post-irradiation melanogenesis.