The effect of H1and H2receptor antagonists on melanogenesis | Zendy

Tag S. Anbar | Zendy; Nehal El Badawy | Zendy; TalalA Abd El-Raheem | Zendy; AzzaH Ali | Zendy; Wiete Westerhof | Zendy; Amal T. AbdelRahman | Zendy; SaadeaR Sayed | Zendy; H.T. Salem | Zendy

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The effect of H₁and H₂receptor antagonists on melanogenesis

Author(s) -

Tag S. Anbar,

Nehal El Badawy,

TalalA Abd El-Raheem,

AzzaH Ali,

Wiete Westerhof,

Amal T. AbdelRahman,

SaadeaR Sayed,

H.T. Salem

Publication year - 2011

Publication title -

indian journal of dermatology venereology and leprology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.514

H-Index - 45

eISSN - 0973-3922

pISSN - 0378-6323

DOI - 10.4103/0378-6323.90948

Subject(s) - melanosome , antagonist , histamine , chemistry , pharmacology , receptor , melanin , receptor antagonist , histamine h1 receptor , endocrinology , biology , biochemistry

Histamine was found to stimulate melanogenesis in cultured human melanocytes specifically mediated by histamine H 2 receptors via protein kinase A activation. Based on this finding, the effect of topically applied H 2 antagonist on UVB-irradiated Guinea pigs' skin was examined and found to be suppressive on the post-irradiation melanogenesis.

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