Open AccessLangerhans cell histiocytosis: An uncommon presentation, successfully treated by thalidomide
Author(s) -
Mohammad ShahidiDadras,
Mohammad Saeedi,
Safoura Shakoei,
Azin Ayatollahi
Publication year - 2011
Publication title -
indian journal of dermatology, venereology, and leprology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.514
H-Index - 45
eISSN - 0973-3922
pISSN - 0378-6323
DOI - 10.4103/0378-6323.84064
Subject(s) - langerhans cell histiocytosis , presentation (obstetrics) , medicine , dermatology , thalidomide , rare disease , histiocytosis , disease , surgery , pathology , multiple myeloma
Langerhans cell histiocytosis (LCH) is a rare disease and generally affects children under 15 years of age. Adult onset form and cutaneous features at presentation are uncommon. There are some options for treatment of the skin lesions of LCH such as topical and intralesional corticosteroid, nitrogen mustard, etc., which are not completely curative. Herein, we report a case of perianal LCH in a 20-year-old man with one-year history of recalcitrant well-demarcated, erythematous, and ulcerated plaque surrounding the anal orifice, with pain and difficulty in defecation that was successfully treated with thalidomide.