Open AccessSpontaneous regression of a congenital melanocytic nevus
Author(s) -
Amiya Kumar Nath,
Devinder Mohan Thappa,
Rajesh Nachiappa Ganesh
Publication year - 2011
Publication title -
indian journal of dermatology, venereology, and leprology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.514
H-Index - 45
eISSN - 0973-3922
pISSN - 0378-6323
DOI - 10.4103/0378-6323.82418
Subject(s) - depigmentation , vitiligo , congenital melanocytic nevus , stain , histopathology , nevus , lesion , dermatology , pathology , medicine , lymphocytic infiltration , melanoma , staining , cancer research
Congenital melanocytic nevus (CMN) may rarely regress which may also be associated with a halo or vitiligo. We describe a 10-year-old girl who presented with CMN on the left leg since birth, which recently started to regress spontaneously with associated depigmentation in the lesion and at a distant site. Dermoscopy performed at different sites of the regressing lesion demonstrated loss of epidermal pigments first followed by loss of dermal pigments. Histopathology and Masson-Fontana stain demonstrated lymphocytic infiltration and loss of pigment production in the regressing area. Immunohistochemistry staining (S100 and HMB-45), however, showed that nevus cells were present in the regressing areas.