Open AccessGranulomatous mycosis fungoides with hypohidrosis mimicking lepromatous leprosy
Author(s) -
Rameshwar Gutte,
Vidya Kharkar,
Sunanda Mahajan,
Siddhi Chikhalkar,
Uday Khopkar
Publication year - 2010
Publication title -
indian journal of dermatology, venereology, and leprology
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.514
H-Index - 45
eISSN - 0973-3922
pISSN - 0378-6323
DOI - 10.4103/0378-6323.72470
Subject(s) - mycosis fungoides , medicine , axillary lymphadenopathy , pathology , dermatology , prednisolone , skin biopsy , lymphoma , biopsy , surgery , cancer , breast cancer
Granulomatous mycosis fungoides (GMF) is a rare type of cutaneous T cell lymphoma. A 38-year-old married male presented with decreased sweating all over the body for last 8 years, progressive redness and scaling over body for 2 years and multiple noduloulcerative lesions over the body for 1 year. Cutaneous examination revealed generalized erythema and scaling with poikilodermatous changes over chest and upper back along with multiple noduloulcerative lesions. Skin biopsy from a nodular lesion revealed dense granulomatous infiltrate of atypical lymphocytes with epidermotropism and sparing of appendages. Diagnosis of GMF was made. Computed tomographic scan of thorax, abdomen and pelvis revealed axillary and inguinal lymphadenopathy. Immunohistochemistry revealed leukocyte common antigen and CD3 positivity suggestive of T cell origin. Patient was started on CHOP (Cyclophosphamide, Hydroxydaunorubicin, Oncovin and Prednisolone) regimen of chemotherapy with marked improvement after three cycles of chemotherapy. This case had some clinical resemblance to lepromatous leprosy.