Open AccessNephrogenic fibrosing dermopathy
Author(s) -
S Ragunatha,
Aparna Palit,
Arun C Inamadar,
Ravindra M Madraki,
B R Yelikar
Publication year - 2009
Publication title -
indian journal of dermatology, venereology, and leprology
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.514
H-Index - 45
eISSN - 0973-3922
pISSN - 0378-6323
DOI - 10.4103/0378-6323.45224
Subject(s) - medicine , chronic renal failure , pathology , contracture , cd68 , hemodialysis , immunohistochemistry , surgery
An adult female patient on hemodialysis for chronic renal failure presented with large, brownish, and indurated plaques with bound-down skin on both lower limbs and abdomen along with difficulty in movement of the legs. Histopathological features revealed thick collagen bundles admixed with mucin and intercalating spindle-like cells characteristic of nephrogenic fibrosing dermopathy (NFD). Immunohistochemical study showed prominent CD68 positivity and weak CD34 positivity suggesting that the plaques were more than 20-weeks old. NFD in patients with chronic renal failure of unknown cause is a poor prognostic indicator. Early detection before the development of contracture and prompt treatment of NFD and underlying renal failure may reverse this disabling condition.