Open AccessDifferential expression of solute carrier family 11a member 1 and inducible nitric oxide synthase 2 in skin biopsies from leprosy patients
Author(s) -
Ana Laura PereiraSuárez,
Anabell Alvarado-Navarro,
Juan Gabriel Barrietos-García,
Ciro Estrada-Chávez,
José Francisco MuñozValle,
Mary FafutisMorris
Publication year - 2015
Publication title -
indian journal of dermatology, venereology, and leprology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.514
H-Index - 45
eISSN - 0973-3922
pISSN - 0378-6323
DOI - 10.4103/0378-6323.168345
Subject(s) - lepromatous leprosy , mycobacterium leprae , leprosy , tuberculoid leprosy , nitric oxide synthase , immunology , immunohistochemistry , cd68 , immune system , biology , medicine , pathology , nitric oxide , endocrinology
Leprosy is a chronic granulomatous infection caused by Mycobacterium leprae, an intracellular parasite that resides within macrophages and cannot be eliminated effectively. Solute carrier family 11a member 1 (Slc11a1) and inducible nitric oxide synthase (iNOS), both expressed in macrophages, play major roles in host defense against several intracellular pathogens. However, the roles of these molecules in natural infection with M. leprae remain unknown.