Drug Eruptions Induced by Allopurinol Associated with HLA-BFNx015801 | Zendy

Hong Sang | Zendy; Meihua Zeng | Zendy; M. Zhang | Zendy; Fang Liu | Zendy; Wenliang Yan | Zendy; Qingtao Kong | Zendy

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Drug Eruptions Induced by Allopurinol Associated with HLA-BFNx015801

Author(s) -

Hong Sang,

Meihua Zeng,

M. Zhang,

Fang Liu,

Wenliang Yan,

Qingtao Kong

Publication year - 2015

Publication title -

indian journal of dermatology venereology and leprology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.514

H-Index - 45

eISSN - 0973-3922

pISSN - 0378-6323

DOI - 10.4103/0378-6323.148566

Subject(s) - allopurinol , hyperuricemia , gout , medicine , drug , human leukocyte antigen , dermatology , pharmacology , uric acid , immunology , antigen

Allopurinol, a drug commonly used for treating gout and hyperuricemia, is a frequent cause of drug eruptions. Recent investigations suggest that HLA-BFNx015801 allele is a very strong marker for allopurinol-induced cutaneous adverse drug reactions (cADRs). In this article we report two cases of allopurinol-induced drug eruptions in patients carrying the HLA-BFNx015801 allele and review the literature on the association between HLA-BFNx015801 and allopurinol-induced cADRs based on a MEDLINE and PubMed search.

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