Open AccessSevere combined immunodeficiency mouse-psoriatic human skin xenograft model: A modern tool connecting bench to bedside
Author(s) -
Smriti KunduRaychaudhuri,
Ananya Datta-Mitra,
Christine Abria,
John H. Peters,
S. P. Raychaudhuri
Publication year - 2014
Publication title -
indian journal of dermatology, venereology, and leprology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.514
H-Index - 45
eISSN - 0973-3922
pISSN - 0378-6323
DOI - 10.4103/0378-6323.132247
Subject(s) - psoriasis , medicine , animal model , immunology , immunodeficiency , disease , inflammation , severe combined immunodeficiency , angiogenesis , pathogenesis , bench to bedside , dermatology , cancer research , immune system , biology , pathology , in vivo , microbiology and biotechnology , medical physics
Psoriasis is a multifactorial chronic inflammatory disease. Research into the pathogenesis of this disease is hindered by the lack of a proper animal model. Over the past two decades, many scientists were involved in the development of animal models that nearly mirror the immunopathogenesis of psoriasis. One such model, which has opened doors to the study of molecular complexities of psoriasis as well as its treatment, is the severe combined immunodeficiency (SCID) mouse-human skin chimera model. This model not only mirrors the clinical and histopathological features of psoriasis but also help in the study of cell proliferation, angiogenesis, function of T cells, neurogenic inflammation and cytokines involved in inflammatory reactions. In this article, we have reviewed the prospects and the limitations of the SCID mouse model of psoriasis.