Evaluation of the combination of BP180-NC16a enzyme-linked immunosorbent assay and BP230 enzyme-linked immunosorbent assay in the diagnosis of bullous pemphigoid | Zendy

Furen Zhang | Zendy; Baoqi Yang | Zendy; Chong Wang | Zendy; Shengli Chen | Zendy; Xuechao Chen | Zendy; Xianmei Lu | Zendy; Hongqing Tian | Zendy; Meiling Yu | Zendy; Dizhan Zhang | Zendy; Zhongxiang Shi | Zendy; Guizhi Zhou | Zendy

Open Access

Evaluation of the combination of BP180-NC16a enzyme-linked immunosorbent assay and BP230 enzyme-linked immunosorbent assay in the diagnosis of bullous pemphigoid

Author(s) -

Furen Zhang,

Baoqi Yang,

Chong Wang,

Shengli Chen,

Xuechao Chen,

Xianmei Lu,

Hongqing Tian,

Meiling Yu,

Dizhan Zhang,

Zhongxiang Shi,

Guizhi Zhou

Publication year - 2012

Publication title -

indian journal of dermatology venereology and leprology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.514

H-Index - 45

eISSN - 0973-3922

pISSN - 0378-6323

DOI - 10.4103/0378-6323.102364

Subject(s) - bullous pemphigoid , iif , autoantibody , antibody , medicine , microbiology and biotechnology , immunology , virology , biology

Bullous pemphigoid (BP) is an acquired autoimmune subepidermal blistering disease characterized by circulating IgG autoantibodies directed against BP180 and BP230 hemidesmosomal proteins. Previous studies have demonstrated that antibodies against the NC16a domain of BP180 mediate BP pathogenesis, while antibodies against BP230 enhance the inflammatory response. Recently, commercial BP180-NC16a enzyme-linked immunosorbent assay (ELISA) and BP230 ELISA kits were developed to detect anti-BP180 and anti-BP230 autoantibodies in human BP sera.

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