Open AccessPhiladelphia chromosome detection in chronic myeloid leukemia: Utility of phytohemagglutinin-stimulated peripheral blood culture
Author(s) -
Man Updesh Singh Sachdeva,
Neelam Varma,
KS Rana,
Subhash Varma
Publication year - 2012
Publication title -
indian journal of pathology and microbiology/indian journal of pathology and microbiology
Language(s) - English
Resource type - Journals
eISSN - 0974-5130
pISSN - 0377-4929
DOI - 10.4103/0377-4929.97867
Subject(s) - peripheral blood , myeloid leukemia , bone marrow , medicine , cytogenetics , philadelphia chromosome , chromosome , imatinib mesylate , peripheral , imatinib , leukemia , immunology , chromosomal translocation , gastroenterology , pathology , biology , genetics , gene
The conventional cytogenetic approach to demonstrate Philadelphia (Ph) chromosome at times does not yield enough number of metaphases or are of suboptimal quality. Further, the rapid molecular tests have completely pushed this simple technique into disrepute.