Open AccessHemophagocytic syndrome associated with Plasmodium falciparum infection
Author(s) -
PN Vinoth,
Ketas Thomas,
S Muthamil Selvan,
D Febe Renjitha Suman,
Julius Xavier Scott
Publication year - 2011
Publication title -
indian journal of pathology and microbiology/indian journal of pathology and microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.217
H-Index - 31
eISSN - 0974-5130
pISSN - 0377-4929
DOI - 10.4103/0377-4929.85105
Subject(s) - hemophagocytosis , pancytopenia , hepatosplenomegaly , medicine , plasmodium falciparum , malaria , bone marrow , immunology , hypertriglyceridemia , pathology , disease , triglyceride , cholesterol
Hemophagocytic syndrome (HPS) has been associated with infections, hematological malignancies and autoimmune conditions. Malaria is rarely reported to cause HPS. We report a case of an 11-month-old infant with fever, hepatosplenomegaly, pancytopenia, high serum ferritin, hypertriglyceridemia, and bone marrow hemophagocytosis, consistent with hemophagocytic syndrome. Gametocytes of plasmodium falciparum were identified on bone marrow aspiration. Rapid recovery was observed after treatment with antimalarials.