Open AccessIncreased expression of COX-2 in recurrent basal cell carcinoma of the skin: A pilot study
Author(s) -
Nermin Karahan,
Şirin Başpınar,
Kemal Kürşat Bozkurt,
Eylem Caloglu,
İbrahim Metin Çiriş,
Nilgün Kapucuoğlu
Publication year - 2011
Publication title -
indian journal of pathology and microbiology/indian journal of pathology and microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.217
H-Index - 31
eISSN - 0974-5130
pISSN - 0377-4929
DOI - 10.4103/0377-4929.85086
Subject(s) - immunohistochemistry , basal cell carcinoma , matrix metalloproteinase , pathology , medicine , basal (medicine) , metastasis , angiogenesis , proportional hazards model , extracellular matrix , cancer , cancer research , basal cell , biology , insulin , microbiology and biotechnology
Basal cell carcinoma (BCC) is the most frequent malignant skin tumor. BCC rarely metastasizes, but it is often locally aggressive. Cyclooxygenase-2 (COX-2) is critical for tumor formation, angiogenesis and metastasis. Matrix metalloproteinases (MMPs) are the members of the family of zinc (Zn)- and calcium-dependent endopeptidases that degrade the extracellular matrix.