Increased expression of COX-2 in recurrent basal cell carcinoma of the skin: A pilot study | Zendy

KemalKursat Bozkurt | Zendy; Nermin Karahan | Zendy; Sirin Baspinar | Zendy; Eylem Caloglu | Zendy; IbrahimMetin Ciris | Zendy; Nilgün Kapucuoğlu | Zendy

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Increased expression of COX-2 in recurrent basal cell carcinoma of the skin: A pilot study

Author(s) -

KemalKursat Bozkurt,

Nermin Karahan,

Sirin Baspinar,

Eylem Caloglu,

IbrahimMetin Ciris,

Nilgün Kapucuoğlu

Publication year - 2011

Publication title -

indian journal of pathology and microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.217

H-Index - 31

eISSN - 0974-5130

pISSN - 0377-4929

DOI - 10.4103/0377-4929.85086

Subject(s) - immunohistochemistry , basal cell carcinoma , matrix metalloproteinase , pathology , medicine , basal (medicine) , metastasis , angiogenesis , proportional hazards model , extracellular matrix , cancer , cancer research , basal cell , biology , insulin , microbiology and biotechnology

Basal cell carcinoma (BCC) is the most frequent malignant skin tumor. BCC rarely metastasizes, but it is often locally aggressive. Cyclooxygenase-2 (COX-2) is critical for tumor formation, angiogenesis and metastasis. Matrix metalloproteinases (MMPs) are the members of the family of zinc (Zn)- and calcium-dependent endopeptidases that degrade the extracellular matrix.

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