Open AccessHepsin immunohistochemical expression in prostate cancer in relation to Gleason′s grade and serum prostate specific antigen
Author(s) -
Madhu Mati Goel,
Dhamita Agrawal,
SM Natu,
Apul Goel
Publication year - 2011
Publication title -
indian journal of pathology and microbiology/indian journal of pathology and microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.217
H-Index - 31
eISSN - 0974-5130
pISSN - 0377-4929
DOI - 10.4103/0377-4929.85078
Subject(s) - hyperplasia , medicine , intraepithelial neoplasia , prostate , prostatitis , prostate cancer , immunohistochemistry , pca3 , pathology , cancer , prostate specific antigen , prostatic diseases
Hepsin (HPN), a type II trans-membrane serine protease, has been reported to be one of the most up regulated genes in prostate cancer. The aim of the present study was to find out immuno-histochemistry based phenotypic expression of HPN in formalin fixed paraffin embedded sections of prostate cancer compared with that in benign prostatic hyperplasia, in a prospective clinical setting, to know the differential status of HPN expression in benign and malignant prostatic disease.