Hepsin immunohistochemical expression in prostate cancer in relation to Gleason′s grade and serum prostate specific antigen | Zendy

MadhuMati Goel | Zendy; Dhamita Agrawal | Zendy; Sm Natu | Zendy; Apul Goel | Zendy

Open Access

Hepsin immunohistochemical expression in prostate cancer in relation to Gleason′s grade and serum prostate specific antigen

Author(s) -

MadhuMati Goel,

Dhamita Agrawal,

Sm Natu,

Apul Goel

Publication year - 2011

Publication title -

indian journal of pathology and microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.217

H-Index - 31

eISSN - 0974-5130

pISSN - 0377-4929

DOI - 10.4103/0377-4929.85078

Subject(s) - hyperplasia , medicine , intraepithelial neoplasia , prostate , prostatitis , prostate cancer , immunohistochemistry , pca3 , pathology , cancer , prostate specific antigen , prostatic diseases

Hepsin (HPN), a type II trans-membrane serine protease, has been reported to be one of the most up regulated genes in prostate cancer. The aim of the present study was to find out immuno-histochemistry based phenotypic expression of HPN in formalin fixed paraffin embedded sections of prostate cancer compared with that in benign prostatic hyperplasia, in a prospective clinical setting, to know the differential status of HPN expression in benign and malignant prostatic disease.

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