Open AccessStrong BCL2 expression in Burkitt lymphoma is not uncommon in adults
Author(s) -
Shahid Pervez,
Muhammad Raheel Raza,
Arslan Mirza,
Anam Pal
Publication year - 2011
Publication title -
indian journal of pathology and microbiology/indian journal of pathology and microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.217
H-Index - 31
eISSN - 0974-5130
pISSN - 0377-4929
DOI - 10.4103/0377-4929.81599
Subject(s) - immunohistochemistry , lymphoma , diffuse large b cell lymphoma , pathology , fish <actinopterygii> , staining , burkitt's lymphoma , monoclonal , medicine , fluorescence in situ hybridization , in situ hybridization , b cell , antibody , monoclonal antibody , biology , gene expression , gene , immunology , genetics , fishery , chromosome
The distinction between Burkitt lymphoma (BL) and diffuse large B-cell lymphoma (DLBCL) is not always easy, so much so that the WHO 2008 Blue Book has incorporated a provisional category of "B-cell lymphoma, unclassifiable with features intermediate between DLBCL and BL." One of the immunohistochemical (IHC) markers used at times to differentiate between the two is IHC expression of BCL2, which was initially believed to be consistently negative in BL. Later it was recognized that weak BCL2 expression is still compatible with the diagnosis of BL. To verify or otherwise this current view this study was undertaken.