Open AccessExpression of erythropoietin and its receptor increases in colonic neoplastic progression: The role of hypoxia in tumorigenesis
Author(s) -
Zoltán Gombos,
Ľ Danihel,
Vanda Repiská,
Géza Ács,
Emma E. Furth
Publication year - 2011
Publication title -
indian journal of pathology and microbiology/indian journal of pathology and microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.217
H-Index - 31
eISSN - 0974-5130
pISSN - 0377-4929
DOI - 10.4103/0377-4929.81591
Subject(s) - erythropoietin receptor , erythropoietin , immunohistochemistry , adenoma , pathology , hypoxia (environmental) , carcinogenesis , medicine , carcinoma , immunostaining , colorectal cancer , cancer research , biology , cancer , chemistry , organic chemistry , oxygen
Tissue hypoxia is a characteristic patho-physiologic property of colorectal cancer. This process may also add to a therapeutic problem of solid tumor resistance to chemo- and radiation therapy. Erythropoietin (Epo) expression is induced by tissue hypoxia. Acting via its receptor (EpoR), Epo inhibits apoptosis of erythroid cells and has been shown to rescue neurons from hypoxic damage. Increased Epo and EpoR expression has been recently described in human breast, renal and cervical carcinoma. Given the characteristic tumor diathesis present in majority of colorectal cancers, we examined whether Epo signaling may play a role in colonic neoplastic progression.