Open AccessCALLA negative precursor B lymphoblastic leukemia with MLL gene translocation and an unusual FISH signal pattern
Author(s) -
Sandhya G Devi,
Manu Goyal,
Narayan Ramakrishna,
Sudha Murthy
Publication year - 2011
Publication title -
indian journal of pathology and microbiology/indian journal of pathology and microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.217
H-Index - 31
eISSN - 0974-5130
pISSN - 0377-4929
DOI - 10.4103/0377-4929.77396
Subject(s) - calla , chromosomal translocation , biology , fluorescence in situ hybridization , fusion gene , karyotype , microbiology and biotechnology , fish <actinopterygii> , leukemia , gene rearrangement , acute lymphocytic leukemia , in situ hybridization , gene , lymphoblastic leukemia , genetics , gene expression , antibody , chromosome , fishery , monoclonal antibody
Rearrangements of the mixed lineage leukemia (MLL) gene at 11q23 commonly occur in infants with CALLA negative B lymphoblastic leukemia (B-ALL). Most often, these are detected by conventional karyotyping; however, fluorescent in-situ hybridization (FISH) with the help of a dual-color break-apart probe is used to identify cryptic translocations. When there is an MLL gene translocation, the usual FISH signal pattern is 1 red-1 green-1 yellow fusion signal pattern. We present a case of an infant with CALLA negative precursor B-ALL with a characteristic translocation t(4;11) (q21;q23), however, with an unusual MLL FISH signal pattern.