Open AccessUtility of p63 immunohistochemical stain in differentiating urothelial carcinomas from adenocarcinomas of prostate
Author(s) -
Nasir Ud Din,
Asim Qureshi,
Samina Mansoor
Publication year - 2011
Publication title -
indian journal of pathology and microbiology/indian journal of pathology and microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.217
H-Index - 31
eISSN - 0974-5130
pISSN - 0377-4929
DOI - 10.4103/0377-4929.77326
Subject(s) - medicine , adenocarcinoma , immunohistochemistry , prostate , pathology , carcinoma , stain , urinary bladder , cancer , prostate cancer , context (archaeology) , oncology , urology , staining , biology , paleontology
Prostatic adenocarcinoma and urothelial carcinoma of the urinary bladder are common cancers in men. High grade forms of these tumors may present ambiguous morphologic features that do not permit a definite diagnosis. This distinction between the two tumors has significant staging and therapeutic implications. Hence, an accurate diagnosis is essential for optimal patient care. p63 is a new marker which can be used in this context. It is expressed in most of the urothelial carcinomas and negative in majority of prostatic adenocarcinomas.