Flow cytometric analysis of erythrocytes in paroxysmal nocturnal hemoglobinuria reveals superiority of CD59 as a diagnostic marker compared to CD55 | Zendy

AmarDas Gupta | Zendy; Prashant Tembhare | Zendy; Manisha Ramani | Zendy; Keerti Syed | Zendy

Open Access

Flow cytometric analysis of erythrocytes in paroxysmal nocturnal hemoglobinuria reveals superiority of CD59 as a diagnostic marker compared to CD55

Author(s) -

AmarDas Gupta,

Prashant Tembhare,

Manisha Ramani,

Keerti Syed

Publication year - 2010

Publication title -

indian journal of pathology and microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.217

H-Index - 31

eISSN - 0974-5130

pISSN - 0377-4929

DOI - 10.4103/0377-4929.72042

Subject(s) - cd59 , paroxysmal nocturnal hemoglobinuria , eculizumab , hemoglobinuria , monoclonal antibody , hemolysis , context (archaeology) , decay accelerating factor , immunology , antibody , medicine , pathology , biology , complement system , paleontology

Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired clonal stem cell disorder characterized by complement-mediated hemolysis due to reduced expression of glycosyl phosphatidylinositol-anchored complement deactivating proteins such as CD55 and CD59 on RBC. Flow cytometric analysis of CD55 and CD59 expression by RBC is a reliable tool for the diagnosis of PNH.

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