Open AccessFlow cytometric analysis of erythrocytes in paroxysmal nocturnal hemoglobinuria reveals superiority of CD59 as a diagnostic marker compared to CD55
Author(s) -
Prashant Tembhare,
Manisha Ramani,
Keerti Syed,
Amar Gupta
Publication year - 2010
Publication title -
indian journal of pathology and microbiology/indian journal of pathology and microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.217
H-Index - 31
eISSN - 0974-5130
pISSN - 0377-4929
DOI - 10.4103/0377-4929.72042
Subject(s) - cd59 , paroxysmal nocturnal hemoglobinuria , eculizumab , hemoglobinuria , monoclonal antibody , hemolysis , context (archaeology) , decay accelerating factor , immunology , antibody , medicine , pathology , biology , complement system , paleontology
Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired clonal stem cell disorder characterized by complement-mediated hemolysis due to reduced expression of glycosyl phosphatidylinositol-anchored complement deactivating proteins such as CD55 and CD59 on RBC. Flow cytometric analysis of CD55 and CD59 expression by RBC is a reliable tool for the diagnosis of PNH.