Open AccessDetermining the relationship between "microvessel density" and different grades of astrocytoma based on immunohistochemistry for "factor VIII-related antigen" (von Willebrand factor) expression in tumor microvessels
Author(s) -
Parvin Mahzouni,
Fereshteh Mohammadizadeh,
Kourosh Mougouei,
Noushin Afshar Moghaddam,
Ali Chehrei,
Alireza Mesbah
Publication year - 2010
Publication title -
indian journal of pathology and microbiology/indian journal of pathology and microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.217
H-Index - 31
eISSN - 0974-5130
pISSN - 0377-4929
DOI - 10.4103/0377-4929.71996
Subject(s) - pathology , immunohistochemistry , microvessel , astrocytoma , staining , stain , angiogenesis , von willebrand factor , h&e stain , medicine , neovascularization , glioma , cancer research , platelet
Astrocytic brain tumors are the most common primary central nervous system tumors, which are classified into four grades. One of the most important pathologic criteria for the diagnosis of higher-grade astrocytomas (especially glioblastoma multiforme) is microvessel proliferation, particularly in the form of glomeruloid complex. Because tumor angiogenesis is a necessary factor for growth and invasiveness of malignancies, microvessel density (MVD) and intensity of angiogenesis may be used to determine the grade of astrocytomas and plan therapy accordingly. We have planned this study to evaluate the relationship between vwf expression in microvessels and different grades of astrocytoma.