Open AccessImmunohistochemical study of epithelial-myofibroblast interaction in Barrett metaplasia
Author(s) -
O Ochicha,
J. H. Pringle,
AZ Mohammed
Publication year - 2010
Publication title -
indian journal of pathology and microbiology/indian journal of pathology and microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.217
H-Index - 31
eISSN - 0974-5130
pISSN - 0377-4929
DOI - 10.4103/0377-4929.64341
Subject(s) - myofibroblast , immunohistochemistry , metaplasia , pathology , epithelium , medicine , chemistry , fibrosis
Sub-epithelial myofibroblasts are known to influence the biology (proliferation, differentiation and apoptosis) of overlying epithelia. In the intestine, myofibroblasts have been demonstrated to be essential for epithelial differentiation. It is therefore hypothesized that myofibroblasts may also be involved in intestinal metaplasia that is characteristic of Barrett esophagus.