Open AccessProtein p16INK4Aexpression in cervical intraepithelial neoplasia and invasive squamous cell carcinoma of uterine cervix
Author(s) -
Ruchika Gupta,
Radhika Srinivasan,
Raje Nijhawan,
Vanita Suri,
Radha Uppal
Publication year - 2010
Publication title -
indian journal of pathology and microbiology/indian journal of pathology and microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.217
H-Index - 31
eISSN - 0974-5130
pISSN - 0377-4929
DOI - 10.4103/0377-4929.59174
Subject(s) - cervical intraepithelial neoplasia , immunohistochemistry , pathology , hpv infection , koilocyte , cervix , epithelium , intraepithelial neoplasia , population , biology , medicine , cancer research , cervical cancer , cancer , environmental health , prostate
The association of human papilloma virus (HPV) infection and cervical intraepithelial neoplasia (CIN) is well recognized. Interaction of HPV oncogenic proteins with cellular regulatory proteins leads to up regulation of p16 INK4A , a CDK inhibitor, which is a biomarker for HPV infection. We investigated p16 expression in CIN and invasive squamous cell carcinoma (SCC) which has not been reported in the Indian population previously.