Protein p 16INK4A expression in cervical intraepithelial neoplasia and invasive squamous cell carcinoma of uterine cervix | Zendy

Radhika Srinivasan | Zendy; Ruchika Gupta | Zendy; Raje Nijhawan | Zendy; Vanita Suri | Zendy; Radha Uppal | Zendy

Open Access

Protein p^16INK4A expression in cervical intraepithelial neoplasia and invasive squamous cell carcinoma of uterine cervix

Author(s) -

Radhika Srinivasan,

Ruchika Gupta,

Raje Nijhawan,

Vanita Suri,

Radha Uppal

Publication year - 2010

Publication title -

indian journal of pathology and microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.217

H-Index - 31

eISSN - 0974-5130

pISSN - 0377-4929

DOI - 10.4103/0377-4929.59174

Subject(s) - cervical intraepithelial neoplasia , immunohistochemistry , pathology , hpv infection , koilocyte , cervix , epithelium , intraepithelial neoplasia , population , biology , medicine , cancer research , cervical cancer , cancer , environmental health , prostate

The association of human papilloma virus (HPV) infection and cervical intraepithelial neoplasia (CIN) is well recognized. Interaction of HPV oncogenic proteins with cellular regulatory proteins leads to up regulation of p16 INK4A , a CDK inhibitor, which is a biomarker for HPV infection. We investigated p16 expression in CIN and invasive squamous cell carcinoma (SCC) which has not been reported in the Indian population previously.

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