Open AccessChanging trends in antimicrobial resistance ofSalmonellaentericaserovar typhi andsalmonella entericaserovar paratyphi A in Chennai
Author(s) -
Padma Krishnan,
M Stalin,
Sundaram Balasubramanian
Publication year - 2009
Publication title -
indian journal of pathology and microbiology/indian journal of pathology and microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.217
H-Index - 31
eISSN - 0974-5130
pISSN - 0377-4929
DOI - 10.4103/0377-4929.56140
Subject(s) - microbiology and biotechnology , nalidixic acid , ciprofloxacin , chloramphenicol , cefixime , ampicillin , salmonella , salmonella enterica , phage typing , salmonella typhi , serotype , drug resistance , virology , biology , cephalosporin , broth microdilution , antimicrobial , antibiotics , minimum inhibitory concentration , bacteria , escherichia coli , biochemistry , genetics , gene
Chloramphenicol was considered the anti-microbial gold standard for typhoid treatment but, following the increasing worldwide frequency of antibiotic resistance, ciprofloxacin has been the mainstay of therapy since 1980. Recent studies have shown a shifting of susceptibility to conventional drugs like chloramphenicol, ampicillin and cotrimoxazole. The primary objective of the study was to evaluate the in vitro activity of chloramphenicol and other first-line drugs in comparison with cephalosporins and quinolones.