Open AccessHemophagocytic syndrome: A cause for fatal outcome in tuberculosis
Author(s) -
Anupama P Gupta,
Sanjay N Parate,
S. K. Bobhate,
. Anupriya
Publication year - 2009
Publication title -
indian journal of pathology and microbiology/indian journal of pathology and microbiology
Language(s) - English
Resource type - Journals
eISSN - 0974-5130
pISSN - 0377-4929
DOI - 10.4103/0377-4929.48939
Subject(s) - hepatosplenomegaly , medicine , phagocytosis , immunology , bone marrow , haematopoiesis , tuberculosis , evans syndrome , generalized lymphadenopathy , lymphoma , pathology , biology , antibody , stem cell , autoimmune hemolytic anemia , disease , genetics
Hemophagocytic syndrome is rare syndrome characterized by unregulated proliferation and activation of macrophages and phagocytosis of the platelet, erythrocytes, lymphocytes and their hematopoietic precursors in the bone marrow, resulting in cytopenias. It is associated with stimuli-like infections, malignancies and immunocompromised states. We present here a case of generalized lymphadenopathy, hepatosplenomegaly and progressive cytopenias in a 17-year-old male.