Open AccessPrimary Langerhans cell histiocytosis of the vulva: Report of a case and brief review of the literature
Author(s) -
Zenggang Pan,
Sanjeev Sharma,
Poonam Sharma
Publication year - 2009
Publication title -
indian journal of pathology and microbiology/indian journal of pathology and microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.217
H-Index - 31
eISSN - 0974-5130
pISSN - 0377-4929
DOI - 10.4103/0377-4929.44968
Subject(s) - langerhans cell histiocytosis , vulva , histopathology , presentation (obstetrics) , medicine , pathology , immunohistochemistry , dermatology , histiocytosis , disease , radiology
Primary Langerhans cell histiocytosis (LCH) of the vulva is rare. Fifteen cases of primary cutaneous vulvar LCH have been reported in English literature. We report an additional case of LCH confined to the vulva. In this article, we describe the clinical presentation, histopathology and immunohistochemistry findings of vulvar LCH that are helpful to both gynecologists and pathologists in the diagnosis of this entity. We briefly discuss the pathogenesis of LCH. The debate whether LCH is a reactive or neoplastic entity is still ongoing.