Open AccessCutaneous angiosarcoma in a patient with xeroderma pigmentosum
Author(s) -
Raman Arora,
Alok Sharma,
Ruchika Gupta,
M Vijayaraghavan
Publication year - 2008
Publication title -
indian journal of pathology and microbiology/indian journal of pathology and microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.217
H-Index - 31
eISSN - 0974-5130
pISSN - 0377-4929
DOI - 10.4103/0377-4929.43741
Subject(s) - xeroderma pigmentosum , angiosarcoma , dermatology , medicine , photosensitivity , nucleotide excision repair , pathology , biology , dna repair , genetics , dna , physics , quantum mechanics
Xeroderma pigmentosum (XP) is a rare, autosomal recessive disorder characterized by photosensitivity, cutaneous pigmentary changes, premature skin ageing and development of various cutaneous and internal malignancies at an early age as a result of a defect in nucleotide excision repair following ultraviolet light exposure. Cutaneous angiosarcomas are aggressive neoplasms that are rarely associated with XP. In this communication, we report the case of a 40-year-old male patient with XP who developed an angiosarcoma of the face and discuss the implications of this association in view of recent developments in this field.