Open AccessCytomegalovirus infection with lissencephaly
Author(s) -
Leena Dennis Joseph,
; Pushpalatha,
Sarah Kuruvilla
Publication year - 2008
Publication title -
indian journal of pathology and microbiology/indian journal of pathology and microbiology
Language(s) - Uncategorized
Resource type - Journals
eISSN - 0974-5130
pISSN - 0377-4929
DOI - 10.4103/0377-4929.42534
Subject(s) - lissencephaly , cytomegalovirus , autopsy , fetus , pathology , pregnancy , cytomegalovirus infections , medicine , virology , biology , virus , human cytomegalovirus , herpesviridae , viral disease , biochemistry , genetics , gene
Lissencephaly is a malformation of the brain in which the brain surface is smooth, rather than convoluted. Among the various causes of lissencephaly, infection by a virus during pregnancy plays an important role. Cytomegalovirus (CMV) is an important pathogen causing this anomaly. We present this case of a young female with 24-week-gestation diagnosed on ultrasound as carrying an anomalous fetus with lissencephalic features. At autopsy, there were multiple intra-nuclear CMV inclusions in the brain and the kidneys. This case is presented for its rarity and for the documentation of the tissue localization of CMV inclusions at autopsy.