Open AccessA clinicopathologic study of mantle cell lymphoma in a single center study in India
Author(s) -
Sumeet Gujral,
Aditi Agarwal,
Gota,
Reeir,
Srinath Gupta,
Pai Sk,
Markus Sänger,
Tanuja Shet,
Subramanian PG,
Mary Ann Muckaden,
Siddhartha Laskar
Publication year - 2008
Publication title -
indian journal of pathology and microbiology/indian journal of pathology and microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.217
H-Index - 31
eISSN - 0974-5130
pISSN - 0377-4929
DOI - 10.4103/0377-4929.42503
Subject(s) - mantle cell lymphoma , histopathology , medicine , mantle zone , cd5 , lymphoma , pathology , bone marrow , stage (stratigraphy) , gastroenterology , b cell , germinal center , paleontology , antibody , immunology , biology
We present clinical features, histopathology and results of treatment in cases of mantle cell lymphoma (MCL) at our hospital. We had 93 cases (2.1%) of MCL out of total 4301 cases of non-Hodgkin's lymphoma (NHL) in a 4-year period. It included 68 cases (1.7%) of MCL from 3987 cases of NHL diagnosed on histopathology. Remaining 25 cases (7.9%) diagnosed solely on peripheral blood examination were excluded. Thirty-six (85%) patients had advanced-stage disease. Sixty-three were nodal and five were extranodal (all gastrointestinal tract). Common patterns were diffuse (64%), nodular (25%) and mantle zone type (11%). Sixty-two cases had lymphocytic while six had blastic morphology (all nodal). Tumor cells expressed CD20 (100%), CD43 (94%), CD5 (89%) and cyclin D1 (85%). Bone marrow was involved in 25 (59%) cases. Thirty-two patients could be treated. Median recurrence-free survival was 22.23 months. Diffuse pattern of nodal involvement had a lower overall survival.