Open AccessSplenic lymphoma with villous lymphocytes
Author(s) -
Ritu Gupta,
Shano Naseem,
Shawgi Sukumaran,
Rajesh Kashyap,
Sukhpreet Kaur,
Lily Paul
Publication year - 2008
Publication title -
indian journal of pathology and microbiology/indian journal of pathology and microbiology
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.217
H-Index - 31
eISSN - 0974-5130
pISSN - 0377-4929
DOI - 10.4103/0377-4929.40420
Subject(s) - lymphocytosis , splenic marginal zone lymphoma , medicine , chronic lymphocytic leukemia , pathology , hairy cell leukemia , lymphoma , lymphoproliferative disorders , marginal zone , splenectomy , leukemia , atypical lymphocyte , spleen , immunology , b cell , antibody
Splenic lymphoma with villous lymphocytes (SLVL) is a rare disorder that comprises less than 1% of lymphoid neoplasms. It is the leukemic counterpart of splenic marginal zone lymphoma (SMZL) and is characterized by splenomegaly, often with no lymphadenopathy, moderate lymphocytosis and villous lymphocytes on peripheral blood smear. Here, we report a case of SLVL in a 56-year-old male with very high leukocyte counts, massive splenomegaly and relatively few leukemic cells with subtle villous projections on the surface. This disorder is often confused with other chronic lymphoproliferative disorders, especially chronic lymphocytic leukemia (CLL) and hairy cell leukemia and should be differentiated from them. We are reporting this case to highlight the diagnostic pitfalls associated with this disorder.