Open AccessUnilateral gonadoblastoma with dysgerminoma in normal fertile woman having a child: Extremely rare occurrence with characteristic immunohistomorphology
Author(s) -
M. L. Kulkarni,
Siddhi Gaurish Sinai Khandeparkar,
Avinash R Joshi,
Pallavi V Bhayekar
Publication year - 2016
Publication title -
indian journal of pathology and microbiology/indian journal of pathology and microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.217
H-Index - 31
eISSN - 0974-5130
pISSN - 0377-4929
DOI - 10.4103/0377-4929.191815
Subject(s) - gonadoblastoma , dysgerminoma , virilization , gonad , karyotype , pregnancy , gonadal dysgenesis , pathology , medicine , gynecology , biology , endocrinology , chromosome , ovary , genetics , hormone , androgen , gene
Gonadoblastomas (GBYs) are rare gonadal tumors almost always arising from a dysgenetic gonad with a Y chromosome. Very rarely, GBYs appear in otherwise normal women with a history of pregnancy. The typical histological appearance of GBY can be altered by extensive deposition of basement membrane material, calcification, or overgrowth by a malignant tumor. Less than 10 cases have been reported with normal 46XX karyotype. Only six cases of GBY have been described in pregnant women. We present a unique case of GBY with dysgerminoma in a genotypically and phenotypically normal woman with a history of normal pregnancy, absence of virilization, and characteristic immunohistomorphological features.