Open AccessAcute myeloid leukemia with t(4;12)(q12;p13): A morphological dilemma
Author(s) -
Umang Patel,
S Arun,
Deepak Kumar Mishra,
Mayur Parihar
Publication year - 2016
Publication title -
indian journal of pathology and microbiology/indian journal of pathology and microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.217
H-Index - 31
eISSN - 0974-5130
pISSN - 0377-4929
DOI - 10.4103/0377-4929.191814
Subject(s) - immunophenotyping , cd117 , cytogenetics , myeloid leukemia , myeloid , pathology , dysplasia , medicine , leukemia , cd34 , biology , immunology , flow cytometry , stem cell , gene , genetics , chromosome
Cytogenetics has a pivotal role in risk stratification of acute myeloid leukemia (AML). We report a case of AML with a t(4;12)(q12;p13). To the best of our knowledge, there are about 24 cases of t(4;12) reported in AML which are usually misdiagnosed as lymphoproliferative disorders on morphological assessment. This case showed specific clinical, morphological, and immunophenotypic features such as (1) pseudo lymphoid morphology, (2) dysplasia in granulocytic series, (3) an immature immunophenotype with positivity for CD34 and CD117, and (4) poor treatment response.