Open AccessDo phosphatase of regenerating liver-3, matrix metalloproteinases-2, matrix metalloproteinases-9, and epidermal growth factor receptor-1 predict response to therapy and survival in glioblastoma multiforme?
Author(s) -
Priyanka Soni,
Nuzhat Husain,
Anil Chandra,
Bal Krishna Ojha,
Madan Lal Brahma Bhatt,
Rakesh Kumar Gupta
Publication year - 2016
Publication title -
indian journal of pathology and microbiology/indian journal of pathology and microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.217
H-Index - 31
eISSN - 0974-5130
pISSN - 0377-4929
DOI - 10.4103/0377-4929.188121
Subject(s) - epidermal growth factor receptor , univariate analysis , context (archaeology) , medicine , immunohistochemistry , matrix metalloproteinase , radiation therapy , survival analysis , proportional hazards model , oncology , epidermal growth factor , pathology , multivariate analysis , cancer , receptor , biology , paleontology
Poor survival of the glioblastoma multiforme (GBM) has been attributed in part to the invasive nature of the lesion making complete surgical removal near impossible. Phosphatase of regenerating liver-3 (PRL-3), matrix metalloproteinases-2 and -9 (MMP-2 and MMP-9), and epidermal growth factor receptor (EGFR-1) play a role in invasive nature of tumor cells.