Open AccessA rare case of multicentric secretory carcinoma of breast in an adult female with review of literature
Author(s) -
M. L. Kulkarni,
Siddhi Gaurish Sinai Khandeparkar,
Avinash R Joshi,
Ashish Dhande
Publication year - 2016
Publication title -
indian journal of pathology and microbiology/indian journal of pathology and microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.217
H-Index - 31
eISSN - 0974-5130
pISSN - 0377-4929
DOI - 10.4103/0377-4929.182021
Subject(s) - immunohistochemistry , medicine , breast carcinoma , pathology , rare disease , disease , carcinoma , breast cancer , cancer
Secretory breast carcinomas (SBCs) are considered one of the rarest types of BCs accounting for <0.15% of all breast cancers. The lesions are typically solitary, but rare multicentric cases have been reported. SBC have characteristic histopathological, immunohistochemical, and electron microscopic findings. Children and adolescents with SBC have a favorable prognosis, but disease seems slightly more aggressive in adults. The characteristic ETV6-NTRK3 molecular alteration, leading to a stable chimeric tyrosine kinase fusion product, may be the target of promising new treatment for this unique BC. We present a rare case of multicentric secretory carcinoma of breast with aggressive clinical behavior in a 75-year-old female.