Open AccessAcute monoblastic leukemia with abnormal eosinophils and inversion (16): A rare entity
Author(s) -
Kiruthiga Kala Gnanasekaran,
Mary Purna Chacko,
Marie Therese Manipadam,
Mandeep Singh Bindra,
Biju George,
Vivi M. Srivastava
Publication year - 2016
Publication title -
indian journal of pathology and microbiology/indian journal of pathology and microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.217
H-Index - 31
eISSN - 0974-5130
pISSN - 0377-4929
DOI - 10.4103/0377-4929.174829
Subject(s) - chromosomal inversion , eosinophilia , abnormality , pathology , myeloid leukemia , medicine , myeloid , bone marrow , leukemia , chromosomal abnormality , karyotype , haematopoiesis , chromosome , cancer research , biology , immunology , stem cell , gene , genetics , psychiatry
Acute myeloid leukemia (AML) is a malignant hematopoietic stem cell disorder which is sub-classified based on bone marrow morphology and the presence of specific genetic abnormalities. One such cytogenetic abnormality is the pericentric inversion (inv) of chromosome 16 which is typically seen in AML M4 with eosinophilia and is associated with a favorable prognosis. We report the inv (16) in a young woman with AML M5 and abnormal eosinophils. This is a rare entity with only about 20 cases being reported till date.