Open AccessExtensive intestinal metaplasia of renal pelvis: Report of a case and literature review
Author(s) -
Prakriti Shukla,
Hanni V Gulwani
Publication year - 2015
Publication title -
indian journal of pathology and microbiology/indian journal of pathology and microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.217
H-Index - 31
eISSN - 0974-5130
pISSN - 0377-4929
DOI - 10.4103/0377-4929.168890
Subject(s) - urothelium , renal pelvis , metaplasia , medicine , malignancy , epithelium , intestinal metaplasia , pathology , immunohistochemistry , adenocarcinoma , malignant transformation , squamous metaplasia , ureter , urology , urinary bladder , cancer , dysplasia
Transformation of the urothelium to the intestinal type of epithelium is rare in the pelvis with very few cases reported in the literature. The present study reports extensive intestinal metaplasia of the pelvi-calyceal system without residual urothelium in a 35-years-old woman with a 2 years history of renal calculi. Right - sided Nephrectomy was undertaken. Immunohistochemistry of the metaplastic epithelium revealed positive expression of CK20, low Ki-67 index and negative expression of p53. In this patient long standing metaplastic changes did not progress to adenocarcinoma which indicates that extensive intestinal metaplasia is not always associated with malignancy.