Open AccessChlamydia pneumoniae-related hemophagocytic lymphohistiocytosis in an adult patient with clonal karyotype abnormality
Author(s) -
Zheng-Yi Huang,
Tzong-Shi Chieuh,
Kwei-Shuai Hwang,
TzuChuan Huang
Publication year - 2015
Publication title -
indian journal of pathology and microbiology/indian journal of pathology and microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.217
H-Index - 31
eISSN - 0974-5130
pISSN - 0377-4929
DOI - 10.4103/0377-4929.162928
Subject(s) - hemophagocytic lymphohistiocytosis , pneumonia , immunology , karyotype , chlamydia , medicine , chlamydiaceae , abnormality , disease , biology , pathology , chromosome , gene , genetics , psychiatry
Hemophagocytic lymphohistiocytosis (HLH) is a rare life-threatening disease characterized by a severe hyperinflammation caused by uncontrolled proliferation of activated lymphocytes and macrophages. Herein, we report a 58-year-old male who had Chlamydia pneumoniae-related pneumonia, followed by aggressive HLH. An abnormal cytogenetic profile was also detected. To our knowledge, this is the first report of an adult patient with C. pneumonia-associated HLH.