Open AccessBRAF, KIT, NRAS, GNAQ and GNA11 mutation analysis in cutaneous melanomas in Turkish population
Author(s) -
İsmail Yılmaz,
Mehmet Gamsızkan,
Zafer Küçükodacı,
Ufuk Berber,
Dilaver Demırel,
Aptullah Haholu,
Gizem Narlı
Publication year - 2015
Publication title -
indian journal of pathology and microbiology/indian journal of pathology and microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.217
H-Index - 31
eISSN - 0974-5130
pISSN - 0377-4929
DOI - 10.4103/0377-4929.162831
Subject(s) - gnaq , neuroblastoma ras viral oncogene homolog , exon , mutation , cancer research , medicine , sanger sequencing , population , melanoma , genetics , biology , gene , kras , environmental health
KIT and mitogen-activated protein kinase cascade are important for melanomagenesis. In the present study, we analyzed the frequency of BRAF, NRAS, KIT, GNAQ and GNA11 gene mutations and investigated their association with clinicopathological features of melanomas in Turkish population.