Open AccessFlow cytometric analysis of Mixed phenotype acute leukemia: Experience from a tertiary oncology center
Author(s) -
Renu Saxena,
Rekha A. Nair,
Priya Mary Jacob,
Kunjulekshmi Amma Raveendran Nair Anila,
Shruti Prem,
R. Binitha,
P Kusumakumary
Publication year - 2015
Publication title -
indian journal of pathology and microbiology/indian journal of pathology and microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.217
H-Index - 31
eISSN - 0974-5130
pISSN - 0377-4929
DOI - 10.4103/0377-4929.155309
Subject(s) - immunophenotyping , medicine , acute leukemia , leukemia , myeloid leukemia , myeloid , immunology , antigen
Mixed phenotype acute leukemia (MPAL) is a rare subset of acute leukemia where the blasts exhibit lineage specific antigens of more than one lineage. Flow cytometric immunophenotyping is essential for the diagnosis of MPAL and the accurate diagnosis highly depends on the panel of markers used. The precise incidence of MPAL is uncertain as various institutions use different combinations of antibodies to assign the blasts to a particular lineage.