Open AccessV-raf murine sarcoma viral oncogene homolog B (BRAF) mutations in hairy cell leukaemia
Author(s) -
Neeraj Arora,
Shalini Nair,
Rekha Pai,
Sukesh C. Nair,
Rayaz Ahmed,
Aby Abraham,
Auro Viswabandya,
Biju George,
Poonkuzhali Balasubramanian,
Alok Srivastava,
Vikram Mathews
Publication year - 2015
Publication title -
indian journal of pathology and microbiology/indian journal of pathology and microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.217
H-Index - 31
eISSN - 0974-5130
pISSN - 0377-4929
DOI - 10.4103/0377-4929.151190
Subject(s) - cladribine , hairy cell leukemia , viral oncogene , sanger sequencing , mutation , v600e , lymphoma , medicine , cancer research , mantle cell lymphoma , microbiology and biotechnology , biology , leukemia , pathology , immunology , cancer , genetics , gene
Hairy cell leukemia (HCL) is a B-cell non-Hodgkin lymphoma with distinct clinical, morphological and immunophenotypic features; however, there are many other B-cell lymphomas, which closely mimic HCL. Accurate diagnosis of HCL is important as treatment with 2-chloro-2'-deoxyadenosine (cladribine) is associated with >80% chance of complete cure. The recent description of BRAF p.V600E mutations in almost all HCL cases in various studies has not only improved the pathogenetic understanding of this entity but also increased the diagnostic accuracy of this disorder.