Open AccessStudy of the reproducibility of the 2004 World Health Organization classification of urothelial neoplasms
Author(s) -
Pritee Sharma,
Hema Kini,
Radha R. Pai,
Kaushalya K. Sahu,
Jyoti R. Kini
Publication year - 2015
Publication title -
indian journal of pathology and microbiology/indian journal of pathology and microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.217
H-Index - 31
eISSN - 0974-5130
pISSN - 0377-4929
DOI - 10.4103/0377-4929.151189
Subject(s) - medicine , reproducibility , urothelial carcinoma , urinary bladder , urology , carcinoma , urinary system , bladder tumor , pathology , bladder cancer , radiology , cancer , statistics , mathematics
The aim of the study was to evaluate urinary bladder biopsies showing papillary urothelial neoplastic lesions based on the 2004 WHO/ISUP classification of Urothelial Neoplasms of the Urinary Bladder, to assess the reproducibility of the bladder carcinoma grade. Fifty consecutive transurethral tumor resection biopsies were evaluated by four pathologists independently. The final diagnoses of each pathologist were subjected to statistical analysis to assess the degree of interobserver variability and reproducibility of this classification. Significant interobserver variation was found in the reporting of urothelial neoplasms. In 22 instances there was difference in opinion between PUNLMP and low-grade carcinoma, and in 59 instances between low and high grade carcinoma. The 4 observers never unanimously agreed on the diagnosis of PUNLMP.