Open AccessAdenoid cystic carcinoma of the breast: Report of two cases with immunohistochemical profile of C-kit and MYB overexpression
Author(s) -
Susie Chin,
Zisun Kim
Publication year - 2014
Publication title -
indian journal of pathology and microbiology/indian journal of pathology and microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.217
H-Index - 31
eISSN - 0974-5130
pISSN - 0377-4929
DOI - 10.4103/0377-4929.142693
Subject(s) - adenoid cystic carcinoma , myb , immunohistochemistry , pathology , progesterone receptor , breast carcinoma , estrogen receptor , adenoid , carcinoma , cancer research , basal (medicine) , biology , medicine , breast cancer , cancer , gene expression , gene , biochemistry , insulin
Adenoid cystic carcinoma (ACC) is a rare tumor with characteristic histologic features. Staining with basal markers for estrogen receptor, progesterone receptor, and HER2 usually shows negative results. Immunohistochemical analysis of C-kit and MYB overexpression of the ACC also has been reported. We report two cases of ACC of the breast with C-kit and MYB overexpression that clinically confirm these previously reported characteristics and suggest that further molecular study of the expression of these two proteins can lead to future therapeutic strategies.