Open AccessMolecular characterization of metallo β-lactamase producing multidrug resistant Pseudomonas aeruginosa from various clinical samples
Author(s) -
K. Raman,
Rajagopalan Saranathan,
Sreejayan Nair,
K Prashanth,
Sheela Devi Chandrakesan
Publication year - 2014
Publication title -
indian journal of pathology and microbiology/indian journal of pathology and microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.217
H-Index - 31
eISSN - 0974-5130
pISSN - 0377-4929
DOI - 10.4103/0377-4929.142670
Subject(s) - pseudomonas aeruginosa , microbiology and biotechnology , antibiotics , multiple drug resistance , efflux , polymerase chain reaction , biology , gene , bacteria , antibiotic resistance , drug resistance , genetics
Pseudomonas aeruginosa is a potent opportunistic nosocomial human pathogen among Gram-negative bacteria causing various life-threatening infections in patients from Intensive Care Units. This bacterium has become resistant to almost all commonly available antibiotics with limited treatment options. Multi drug resistant P. aeruginosa (MDRPA) is a major cause of concern among hospital acquired infections. It uses distinctive resistant mechanisms virtually to all the available antibiotics such as Metallo β-lactamases (MBL) production, extended spectrum β-lactamase production (ESBL), up regulation of efflux systems related genes and decreased outer membrane permeability. This study was carried out to find one the predominant resistance mechanisms among MDRPA and the prevalence of corresponding resistance genes.