Open AccessInferior vena cava thrombosis in a case of amoebic liver abscess: Is hypercomplementemia responsible for this rare entity?
Author(s) -
Sudha Chandelia,
Sarika Jain,
Dinesh Kumar Yadav,
Nand Kishore Dubey
Publication year - 2014
Publication title -
indian journal of pathology and microbiology/indian journal of pathology and microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.217
H-Index - 31
eISSN - 0974-5130
pISSN - 0377-4929
DOI - 10.4103/0377-4929.134734
Subject(s) - medicine , thrombosis , inferior vena cava , thrombus , entamoeba histolytica , complication , liver abscess , venous thrombosis , abscess , surgery , immunology
Among the liver abscesses, thrombosis of the inferior vena cava (IVC) has been reported mainly in amoebic liver abscess (ALA) caused by Entamoeba histolytica (E.H). It is an unusual complication especially in paediatric age group. Association of hypercomplementemia and IVC thrombosis has not been discussed previously. Published data suggest that E.H can activate the complement system and can cause hypercomplementemia. A very few studies suggest that complement activation and hypercomplementemia are associated with thrombus formation. We describe a paediatric case of ALA complicated by IVC thrombosis extending to the right atrium and discuss the possible role of hypercomplementemia in causation of IVC thrombosis in cases of ALA.