Expression of tumor necrosis factor-α and nuclear factor-kappaB/RelA and the pathogenesis of psoriasis | Zendy

Nikhil Moorchung | Zendy; Biju Vasudevan | Zendy; NS Mani | Zendy; Rajesh Verma | Zendy

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Expression of tumor necrosis factor-α and nuclear factor-kappaB/RelA and the pathogenesis of psoriasis

Author(s) -

Nikhil Moorchung,

Biju Vasudevan,

NS Mani,

Rajesh Verma

Publication year - 2014

Publication title -

indian journal of pathology and microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.217

H-Index - 31

eISSN - 0974-5130

pISSN - 0377-4929

DOI - 10.4103/0377-4929.134664

Subject(s) - immunostaining , tumor necrosis factor alpha , proinflammatory cytokine , psoriasis , pathogenesis , pathology , basal (medicine) , biology , medicine , immunohistochemistry , immunology , endocrinology , inflammation , insulin

Tumor necrosis factor-α (TNF-α) is an important mediator in the pathogenesis of psoriasis. Nuclear factor-kappaB (NF-κB) is a transcription factor that regulates the activity of the proinflammatory genes. Psoriasis is an inflammatory disease and the role of TNF-α and NF-κB, should be considerable.

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