Open AccessExpression of tumor necrosis factor-α and nuclear factor-kappaB/RelA and the pathogenesis of psoriasis
Author(s) -
Nikhil Moorchung,
Biju Vasudevan,
NS Mani,
Rajesh Verma
Publication year - 2014
Publication title -
indian journal of pathology and microbiology/indian journal of pathology and microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.217
H-Index - 31
eISSN - 0974-5130
pISSN - 0377-4929
DOI - 10.4103/0377-4929.134664
Subject(s) - immunostaining , tumor necrosis factor alpha , proinflammatory cytokine , psoriasis , pathology , pathogenesis , basal (medicine) , biology , cytoplasm , medicine , immunohistochemistry , immunology , inflammation , endocrinology , microbiology and biotechnology , insulin
Tumor necrosis factor-α (TNF-α) is an important mediator in the pathogenesis of psoriasis. Nuclear factor-kappaB (NF-κB) is a transcription factor that regulates the activity of the proinflammatory genes. Psoriasis is an inflammatory disease and the role of TNF-α and NF-κB, should be considerable.